SCIENCE REPORT - New Cold Drug

SCIENCE REPORT - January 2, 2002: New Cold Drug

By Nancy Steinbach
This is the VOA Special English Science Report.

American researchers say they have developed the first drug that can effectively treat adults suffering a viral
respiratory infection called the common cold.

A cold is an infection of the breathing system. About fifty percent of colds are caused by a group of viruses
known as picornaviruses (pa-CORN-a-viruses). These small particles spread from person to person through the
air. The virus first infects the tissues in the nose and throat. Signs of a cold include sore throat, discharge of fluids
from the nose, sneezing, coughing and difficulty breathing. The sinuses, ears and lungs may also become
infected. This can lead to serious conditions like bronchitis or pneumonia 1.

Medical experts say Americans suffer as many as one-thousand-million colds every year. The experts say colds
result in fifty-one-million visits to doctors each year. Yet no treatments are effective against the picornavirus.

Researchers at the ViroPharma company in Exton, Pennsylvania say they have developed such a drug. It is called
pleconaril (pla-CON-ah -rill). The researchers say the drug attacks the picornavirus. It interferes 2 with the infection
process and prevents the virus from reproducing 3.

Researchers at the University of Virginia in Charlottesville studied the drug. They reported the results at an
infectious 4 disease conference in Chicago, Illinois. They said pleconaril reduces the length and severity of a cold.

One study involved more than two-thousand people with colds who were divided into two groups. One group
took four-hundred milligrams of pleconaril three times a day for five days. The other group took an inactive
substance. Sixty-five percent of those in the study had a cold caused by a picornavirus.

The people infected with the picornavirus who took pleconaril suffered from the cold for six days. The others
who took the inactive substance suffered for seven days. The researchers said the drug made people feel better
sooner when the cold was caused by a picornavirus. They also said the drug began to ease the signs of the cold
within one day. And it stopped the discharge of nasal fluids one day sooner than usual.

The United States Food and Drug Administration is examining the research on pleconaril. Officials at
ViroPharma say they expect the drug to be approved later this year.

This VOA Special English Science Report was written by Nancy Steinbach.

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